1-Amino-2-propanol → HCID 9901790, 화합물

HRID 1355356노트

반응식

HRID 1355356 반응식
CS[C:3]1[N:4]=[N:5][C:6]([C:20]#[N:21])=[C:7]([N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=3[CH2:11][CH2:10]2)[N:8]=1.[NH2:22][CH2:23][CH:24]([OH:26])[CH3:25]>O1CCOCC1>[OH:26][CH:24]([CH3:25])[CH2:23][NH:22][C:3]1[N:4]=[N:5][C:6]([C:20]#[N:21])=[C:7]([N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=3[CH2:11][CH2:10]2)[N:8]=1

참가 물질

4

반응물 2

HCID 41-Amino-2-propanolHCID 18506776HCID 18506776, 화합물

생성물 1

HCID 9901790HCID 9901790, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

In analogy to the procedure as described in example 4 the 3-methylsulfanyl-5-(1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-[1,2,4]triazine-6-carbonitrile was reacted with (RS)-1-amino-2-propanol in dioxane at 120° C. overnight to give (RS)-3-(2-hydroxy-propylamino)-5-(1,2,4,5 -tetrahydro-benzo[d]azepin-3-yl)-[1,2,4]triazine-6-carbonitrile as a white solid; MS: 325 (M+H)+.

출처 및 근거

ORD 기록
ord-78b6a1711c0a42e88eb5c55cb64a06b5
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586422B2

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