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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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(2-Chloro-6-methoxypyridin-4-yl)methanol → 2-Chloro-6-methoxypyridine-4-carbaldehyde

HRID 1355471
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HRID 1355471 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O>C(Cl)Cl.CCOCC>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([O:10][CH3:11])[N:3]=1)[CH:8]=[O:9]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 11457961(2-Chloro-6-methoxypyridin-4-yl)methanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 27629762-Chloro-6-methoxypyridine-4-carbaldehyde

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

To a solution of (2-chloro-6-methoxypyridin-4-yl)methanol (1.73 g, 9.97 mmole) from the protocol immediately above in CH2Cl2 (40 ML) was added PCC (2.58 g, 11.96 mmole) all at once at RT. After 60 hr the mixture was diluted with Et2O and filtered through a plug of Celite®. The filtrate was concentrated to give the titled compound as a tan-yellow solid which was sufficiently pure for use in the next step. 1H-NMR (500 MHz, CDCl3) δ9.96 (s, 1H), 7.32 (s, 1H), 7.06 (s, 1H), 4.00 (s, 3H).

후처리

  1. filtrationfiltered through a plug of Celite®
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-d6292a28800643dc941ebe6fcadcc399
출처 데이터셋
uspto-grants-2003_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06586423B2

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