2-Aminopyridine → 6-amino-3-Pyridinepropanol

HRID 1355501노트

반응식

HRID 1355501 반응식
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][OH:11])=[CH:4][CH:3]=1.NC1C=CC=CN=1>CCO.[OH-].[OH-].[Pd+2]>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 104392-AminopyridineHCID 185068563-(6-Aminopyridin-3-yl)prop-2-yn-1-ol

생성물 1

HCID 185068066-amino-3-Pyridinepropanol

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

3-(6-Amino-pyridin-3-yl)-prop-2-yn-1-ol (7-2), 2.73 g (18.4 mmol) and Pd(OH)2 (0.27 g) were stirred in 30 mL EtOH (aminopyridine does not completely dissolve). Reaction was put under one atmosphere of H2 for 24 h. The reaction was filtered through a plug of celite, washed with EtOH, and concnetrated to afford the titled compound as an orange oil. 1H NMR (CDCl3) δ 7.90 (d, 1H, J=2.3 Hz), 7.31 (dd, 1H, J=2.4, 8.6 Hz), 6.43 (d, 1H, J=8.7 Hz), 4.38 (bs, 2H), 3.63 (t, 2H, J=7.5 Hz), 2.58 (t, 2H, J=7.2 Hz), 1.97 (bs, 1H), 1.82 (m, 2H).

후처리

  1. dissolutiondoes not completely dissolve)
  2. customReaction
  3. filtrationThe reaction was filtered through a plug of celite
  4. washwashed with EtOH

출처 및 근거

ORD 기록
ord-fb35f63d604048f59a6f86e25bd95bff
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586424B2

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