Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → 2-Amino-4-(p-chlorophenyl)-6-(methylthio)-pyrimidine-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Guanidine Nitrate | HCID 10481 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-Chlorobenzoylacetonitrile | HCID 138308 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Carbon Disulfide | HCID 6348 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 2-Amino-4-(p-chlorophenyl)-6-(methylthio)-pyrimidine-5-carbonitrile | HCID 4138844 | — |
반응 단계
From 4-chlorobenzoylacetonitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 278 (M{37Cl}+, 14), 277 ([M{37Cl}—H]+, 42), 276 (M{35Cl} +, 46), 275 ([M{35Cl}—H]+, 100), 241 ([M—Cl]+, 30).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06586441B2 |
| 출처 데이터셋 | uspto-grants-2003_07 |
| ORD ID | ord-709d3ddd72b44eba933f13289e622e6d |
| 출처 메모 | uspto-grants-2003_07 |