1,8-Diazabicyclo(5.4.0)undec-7-ene → 4-[(2-Amino-5-cyano-6-furan-2-yl-pyrimidin-4-ylamino)-methyl]-benzenesulfonamide

HRID 1355981노트

반응식

HRID 1355981 반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)=O)[N:3]=1.Cl.NC[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:24][CH:23]=1.C1CCN2C(=[N:36]CCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([NH:36][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:24][CH:23]=2)[C:5]([C:13]#[N:14])=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 123345284-(2-Aminoethyl)benzenesulfonamide hydrochlorideHCID 185076922-Amino-4-(furan-2-YL)-6-(methylsulfinyl)pyrimidine-5-carbonitrile

생성물 1

HCID 185073594-[(2-Amino-5-cyano-6-furan-2-yl-pyrimidin-4-ylamino)-methyl]-benzenesulfonamide

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile, 4-(aminoethyl)benzenesulfonamide hydrochloride and DBU in DME. ES-MS m/e (%): 369 ([M—H]−, 100).

출처 및 근거

ORD 기록
ord-8258e5288c4a40099da571629c7e8d5c
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

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