(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamine → 2-Amino-4-[(3-chloro-5-trifluoromethyl-pyridin-2-yl-methyl)-amino]-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

HRID 1356082노트

반응식

HRID 1356082 반응식
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[O:14][CH:15]=[C:16]([CH3:18])[CH:17]=2)[N:3]=1.[NH2:19][CH2:20][C:21]1[C:26]([Cl:27])=[CH:25][C:24]([C:28]([F:31])([F:30])[F:29])=[CH:23][N:22]=1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([NH:19][CH2:20][C:21]2[C:26]([Cl:27])=[CH:25][C:24]([C:28]([F:31])([F:30])[F:29])=[CH:23][N:22]=2)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[O:14][CH:15]=[C:16]([CH3:18])[CH:17]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 11085087(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamineHCID 185075602-Amino-4-methanesulfinyl-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

생성물 1

HCID 185074132-Amino-4-[(3-chloro-5-trifluoromethyl-pyridin-2-yl-methyl)-amino]-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

From 2-amino-4-methanesulfinyl-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile and 2-aminomethyl-3-chloro-5-(trifluoromethyl)pyridine in DME. ES-MS m/e (%): 411 (M{37Cl}+H+, 35), 409 (M{35Cl}+H+, 100).

출처 및 근거

ORD 기록
ord-a2007de0610d4081a4345793430aade1
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

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