1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-[(isoquinolin-3-yl-methyl)-amino]-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

HRID 1356154

반응식

HRID 1356154 반응식
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1.Cl.Cl.[CH:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[C:22]([CH2:30][NH2:31])[N:21]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([NH:31][CH2:30][C:22]2[N:21]=[CH:20][C:29]3[C:24]([CH:23]=2)=[CH:25][CH:26]=[CH:27][CH:28]=3)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507304Isoquinolin-3-ylmethanamine dihydrochlorideHCID 185075202-Amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

생성물 1

HCID 185072212-Amino-4-[(isoquinolin-3-yl-methyl)-amino]-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

From 2-amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile, C-isoquinolin-3-yl-methylamine dihydrochloride and DBU in DME. ES-MS m/e (%): 343 (M+H+, 100).

출처 및 근거

ORD 기록
ord-e75b44eafd6a46a1affdc19d6bb858a6
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

연결된 노트

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