Dichloromethane → 5-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

반응식

[CH:1]1([c:4]2[n:5][c:6](-[c:12]3[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]3)[n:7][cH:8][c:9]2[CH2:10][OH:11])[CH2:2][CH2:3]1.[Cl:26][CH2:27][Cl:28].[S:22]([Cl:23])([Cl:24])=[O:25]>>[CH:1]1([c:4]2[n:5][c:6](-[c:12]3[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]3)[n:7][cH:8][c:9]2[CH2:10][Cl:24])[CH2:2][CH2:3]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 21935648[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol

생성물 1

HCID 219359605-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

출처 및 근거

ORD 기록: ord-5c2efabbadb441e7ad706701fa49dd20
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

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