Potassium Carbonate → N-Boc-N-methylethylenediamine

HRID 1356451노트

반응식

HRID 1356451 반응식
[C:1]([O:5][C:6](=[O:18])[N:7]([CH3:17])[CH2:8][CH2:9][NH:10]C(=O)C(F)(F)F)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:10][CH2:9][CH2:8][N:7]([CH3:17])[C:6](=[O:18])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 10635722Methyl-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 2756424N-Boc-N-methylethylenediamine수율 70%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of tert-butyl(methyl)[2-[(2,2,2-trifluoroacetyl)amino]ethyl]carbamate (1 g) in methanol (10 ml) in an ice bath was added aqueous 10% potassium carbonate (5 ml). After addition, the reaction mixture was warmed to room temperature and stirring was continued for additional 20 hr. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The insoluble material was removed by filtration and the filtrate was concentrated to obtain the titled compound (451 mg).

후처리

  1. additionAfter addition
  2. concentrationThe reaction mixture was concentrated
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. customThe insoluble material was removed by filtration
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-bf33dcfdf58a4d7faa9109b1524ea199
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586475B1

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