Potassium Carbonate → Ethyl 7-[(2-aminoethyl)(methyl)amino]heptanoate

HRID 1356454노트

반응식

HRID 1356454 반응식
[CH3:1][N:2]([CH2:14][CH2:15][NH:16]C(=O)C(F)(F)F)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[NH2:16][CH2:15][CH2:14][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 18508347Ethyl 7-[methyl-[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]heptanoate

생성물 1

HCID 18508360Ethyl 7-[(2-aminoethyl)(methyl)amino]heptanoate수율 86.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 7-[methyl-[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]heptanoate (4.89 g) in ethanol (80 ml) in an ice bath was added 10% aqueous potassium carbonate (30 ml) and stirring was continued for 20 hr. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The insoluble material was removed by filtration and the filtrate was concentrated to obtain the titled compound (3 g)

후처리

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. customThe insoluble material was removed by filtration
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-24b867b8648744bb9659eaa0bd78a8fe
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586475B1

반응 노트

불러오는 중…