Methanol → HCID 9841041, 화합물

HRID 1356569

반응식

HRID 1356569 반응식
C([O:4][C@H:5]([CH2:10]Br)[CH2:6][C:7]([OH:9])=[O:8])(=O)C.[OH-].[CH2:13]([N+:17]([CH2:26][CH2:27][CH2:28][CH3:29])([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:18][CH2:19][CH2:20][CH3:21])[CH2:14][CH2:15][CH3:16].CO>O>[CH2:26]([N+:17]([CH2:13][CH2:14][CH2:15][CH3:16])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:22][CH2:23][CH2:24][CH3:25])[CH2:27][CH2:28][CH3:29].[O:4]1[CH2:10][C@@H:5]1[CH2:6][C:7]([O-:9])=[O:8]

참가 물질

5

반응물 3

HCID 887MethanolHCID 2723671Tetrabutylammonium HydroxideHCID 2733880(3S)-3-acetyloxy-4-bromobutanoic acid

생성물 1

HCID 9841041HCID 9841041, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a 2 l of three-necked flask equipped with thermometer, pH meter and mechanical stirrer were charged distilled water (1 l), (S)-3-acetoxy-4-bromobutyric acid (90 g, 0.4 mol) and tetrabutylammonium hydroxide, 1.0 M in methanol (1.2 l, 1.2 mol). The reaction mixture was stirred at 0˜5° C. for 2 hours to afford (S)-3,4-epoxybutyric acid tetrabutyl ammonium salt. Over 99% of conversion was detected by NMR.

후처리

  1. customTo a 2 l of three-necked flask equipped with thermometer,
  2. additionwere charged

출처 및 근거

ORD 기록
ord-f1e369a68aa246b19e9fa568ed7e6476
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586616B1

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