Sulfuric Acid → Methyl (3R)-4-cyano-3-hydroxybutanoate
반응식
[C:1]([CH2:3][C@@H:4]([OH:9])[CH2:5][C:6]([OH:8])=[O:7])#[N:2].S(=O)(=O)(O)O.[C:15](=O)([O-])[O-].[Na+].[Na+]>CO>[CH3:15][O:7][C:6](=[O:8])[CH2:5][C@H:4]([OH:9])[CH2:3][C:1]#[N:2]참가 물질
5
실험 절차
(R)-4-cyano-3-hydroxybutyric acid (1.0 mol) in methanol (500 ml) and conc. sulfuric acid (5 g) were refluxed for 5 hours. The reaction mixture was neutralized with sodium carbonate and filtered. The filtrate was concentrated in vacuo to afford (R)-4-cyano-3-hydroxybutyric acid methyl ester (130 g, 91%).
후처리
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-88710c1f836f49869471671e60213968
- 출처 데이터셋
- uspto-grants-2003_07
- 특허 번호
- US06586616B1
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