Water → n-(4-Cyanophenyl)-4-methylbenzenesulfonamide

HRID 1356664노트

반응식

HRID 1356664 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[C:10]1([CH3:20])[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1.O>N1C=CC=CC=1.C(#N)C>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][S:16]([C:13]2[CH:14]=[CH:15][C:10]([CH3:20])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[CH:3][CH:4]=1)#[N:7]

참가 물질

6

반응물 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 133964-Aminobenzonitrile

생성물 1

HCID 257975n-(4-Cyanophenyl)-4-methylbenzenesulfonamide수율 98%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6342Acetonitrile용매

실험 절차

4-Aminobenzonitrile (98%, 500.0 g (4.15 mol) was dissolved in a mixed solvent of pyridine (360 ml) and acetonitrile (900 ml). To this, p-toluenesulfonyl chloride (872.3 g (4.44 mol)) was added with stirring at room temperature. After stirring for 16 hours at room temperature, water (4000 ml) was added to the reaction mixture to bring about separation of crystals. The crystals were filtered and washed with water to give 1153 g (98%) of 4′-cyano-p-toluenesulfonanilide as pale red crude crystals.

후처리

  1. stirringAfter stirring for 16 hours at room temperature
  2. customto bring about separation of crystals
  3. filtrationThe crystals were filtered
  4. washwashed with water

출처 및 근거

ORD 기록
ord-fe1a1a27fabb4a81bff7de403bc264c5
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586617B1

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