Sodium Carbonate → trans-3'-[N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-ethylaminomethyl]acetophenone
반응식
[CH2:1]([NH:3][CH2:4][C:5]1[CH:6]=[C:7]([C:11](=[O:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1)[CH3:2].C(=O)([O-])[O-].[Na+].[Na+].C(=O)([O-])[O-].[K+].[K+].Br[CH2:27][CH:28]=[CH:29][C:30]#[C:31][C:32]([CH3:35])([CH3:34])[CH3:33]>>[CH3:33][C:32]([CH3:35])([CH3:34])[C:31]#[C:30]/[CH:29]=[CH:28]/[CH2:27][N:3]([CH2:4][C:5]1[CH:6]=[C:7]([C:11](=[O:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1)[CH2:1][CH3:2]참가 물질
5
실험 절차
The procedure described in Example 13 was repeated, except that 3′-(N-ethylaminomethyl)acetophenone (1.24 g; 7 mmol), sodium carbonate (instead of potassium carbonate) (745 mg; 7 mmol), and 1-bromo-6,6-dimethyl-2-hepten-4-yn (1.41 g; 7 mmol) were used, to thereby yield 1.30 g of the target compound (yield: 62.5%).