(2S)-1-(4-methylbenzenesulfonyl)pyrrolidine-2-carboxylic acid → HCID 70018574, 화합물

HRID 1356866

반응식

HRID 1356866 반응식
[C:1]1(C)[CH:6]=[CH:5][C:4]([S:7]([N:10]2[CH2:17][CH2:16][CH2:15][C@H:11]2[C:12]([OH:14])=O)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[C:19]1(C)C(S(O)(=O)=O)=CC=CC=1.[CH2:30]([O:37][C:38](=[O:48])[C@H:39]([CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[NH2:40])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:30]([O:37][C:38](=[O:48])[C@H:39]([CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[NH:40][C:12](=[O:14])[C@@H:11]1[CH2:15][CH2:16][CH2:17][N:10]1[S:7]([C:4]1[C:5]([CH3:19])=[CH:6][CH:1]=[CH:2][CH:3]=1)(=[O:8])=[O:9])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

참가 물질

3

반응물 2

HCID 691957(2S)-1-(4-methylbenzenesulfonyl)pyrrolidine-2-carboxylic acidHCID 86587548L-phenylalanine benzyl ester toluenesulfonic acid

생성물 1

HCID 70018574HCID 70018574, 화합물

실험 절차

N-(Toluene-4-sulfonyl)-L-proline was coupled to L-phenylalanine benzyl ester toluenesulfonic acid salt using the procedure described in Method 3 to give the title compound as an oil.

출처 및 근거

ORD 기록
ord-156d5da57b344422b78f2917daef9629
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586602B2

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