Acetyl chloride → Acetamide, N-ethyl-N-(4-nitrophenyl)-
반응식
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1)[CH3:2].[C:13](Cl)(=[O:15])[CH3:14]>C1C=CC=CC=1>[C:13]([N:3]([CH2:1][CH3:2])[C:4]1[CH:5]=[CH:6][C:7]([N+:10]([O-:12])=[O:11])=[CH:8][CH:9]=1)(=[O:15])[CH3:14]참가 물질
4
실험 절차
To a suspension of N-ethyl 4-nitroaniline (1.5 g, 9.026 mmol) in benzene (15 ml), is added acetylchloride (10 ml) and the mixture refluxed for 40 minutes. The solvent is removed by evaporation. The residue is dissolved in ethyl acetate prior to washing with 2N sodium bicarbonate and water, drying (MgSO4) and evaporation. The product is dried under vacuum; ES+ (M+1) 208.57.
후처리
- temperaturethe mixture refluxed for 40 minutes
- customThe solvent is removed by evaporation
- dissolutionThe residue is dissolved in ethyl acetate
- washto washing with 2N sodium bicarbonate and water
- customdrying
- custom(MgSO4) and evaporation
- customThe product is dried under vacuum
출처 및 근거
- ORD 기록
- ord-a467fa6e925242a88b7ed78699b8dc79
- 출처 데이터셋
- uspto-grants-2003_07
- 특허 번호
- US06589950B1
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