Acetamide, N-ethyl-N-(4-nitrophenyl)- → Acetamide, N-(4-aminophenyl)-N-ethyl-

HRID 1356995노트

반응식

HRID 1356995 반응식
[C:1]([N:4]([CH2:14][CH3:15])[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]>C1COCC1.[Pd]>[C:1]([N:4]([CH2:14][CH3:15])[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 74583Acetamide, N-ethyl-N-(4-nitrophenyl)-

생성물 1

HCID 74921Acetamide, N-(4-aminophenyl)-N-ethyl-

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

N-acetyl-N-ethyl-4-nitroaniline (9a) (1.8 g, 8.64 mmol) is hydrogenated in THF (30 ml), over 10%Pd on carbon (100 mg) for 1.5 hours. The catalyst is removed by filtration and the solvent removed evaporation. The product crystalises on standing in hexane, and following filtration, is dried under vacuum; ES+ (M+1) 178.88.

후처리

  1. customfor 1.5 hours
  2. customThe catalyst is removed by filtration
  3. customthe solvent removed
  4. customevaporation
  5. customThe product crystalises
  6. filtrationfiltration
  7. customis dried under vacuum

출처 및 근거

ORD 기록
ord-e61e8923ca8d4396b3db6ca9e2d5bab2
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06589950B1

반응 노트

불러오는 중…