Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Ethylbenzene-1-sulfonyl chloride → (2RS,5SR)-[1-(4-Ethyl-benzenesulfonyl)-5-(4-fluoro-phenyl)-pyrrolidin-2-yl]-methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Ethylbenzene-1-sulfonyl chloride | HCID 570959 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | methyl (2RS,5SR)-5-(4-fluoro-phenyl)-pyrrolidine-2-carboxylate | HCID 67257147 | — |
| 반응물 | methyl (2RS,5SR)-5-(4-fluoro-phenyl)-1-(4-ethyl-benzenesulfonyl)-pyrrolidine-2-carboxylate | HCID 86584369 | — |
| 생성물 | (2RS,5SR)-[1-(4-Ethyl-benzenesulfonyl)-5-(4-fluoro-phenyl)-pyrrolidin-2-yl]-methanol | HCID 69596851 | — |
반응 단계
The title compound, pale yellow oil, MS: m/e=363 (M+) was prepared in accordance with the general methods of example 1d and 84a from methyl (2RS,5SR)-5-(4-fluoro-phenyl)-pyrrolidine-2-carboxylate and 4-ethyl-benzenesulfonyl chloride and subsequent reduction of methyl (2RS,5SR)-5-(4-fluoro-phenyl)-1-(4-ethyl-benzenesulfonyl)-pyrrolidine-2-carboxylate with lithium aluminum hydride according to the general method of example 2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06589978B2 |
| 출처 데이터셋 | uspto-grants-2003_07 |
| ORD ID | ord-a5fdca9f330045f7bba2afe8e81584c8 |
| 출처 메모 | uspto-grants-2003_07 |