Methanol → Methyl 1-benzofuran-2-carboxylate

HRID 1357178

반응식

HRID 1357178 반응식
S(Cl)(Cl)=O.[O:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[C:14]([OH:16])=[O:15].[CH3:17]O>>[O:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[C:14]([O:16][CH3:17])=[O:15]

참가 물질

4

반응물 3

HCID 887MethanolHCID 10331Benzofuran-2-carboxylic acidHCID 24386Thionyl Chloride

생성물 1

HCID 291153Methyl 1-benzofuran-2-carboxylate

실험 절차

After adding thionyl chloride (3.80 ml) to a solution of 2-benzofurancarboxylic acid (2.00 g) in MeOH (60 ml) at −40° C., the mixture was stirred for 19 hours while the temperature gradually increased to room temperature. The reaction solution was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (n-hexane/AcOEt=6/1) to obtain methyl 2-benzofurancarboxylate.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (n-hexane/AcOEt=6/1)

출처 및 근거

ORD 기록
ord-5f4526a0eb564e81b5579c84793da54b
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06589984B1

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