Dimethylformamide → 3-Butyl-benzofuran-2-carbonyl chloride

HRID 1357279노트

반응식

HRID 1357279 반응식
[C:1]([Cl:6])(=[O:5])[C:2](Cl)=[O:3].[CH2:7]([C:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2OC=1C(O)=O)[CH2:8][CH2:9][CH3:10].CN(C=O)C>C(Cl)Cl>[CH2:7]([C:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[O:3][C:2]=1[C:1]([Cl:6])=[O:5])[CH2:8][CH2:9][CH3:10]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 185053403-Butyl-benzofuran-2-carboxylic acid

생성물 1

HCID 185053603-Butyl-benzofuran-2-carbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Oxalyl Chloride (3.86 mL, 44.2 mmol) was added under nitrogen at room temperature to a solution of 3-butyl-benzofuran-2-carboxylic acid (1.93 g, 8.84 mmol) in 60 mL of methylene chloride. After the addition a catalytic amount of DMF (10 μL) was added and the reaction was stirred at room temperature for 2 h. The solvent was removed under reduced pressure. To remove the excess oxalyl chloride the residue was dissolved in benzene and the solvent removed under reduced pressure to give 3-butyl-benzofuran-2-carbonyl chloride, which was immediately used in step 2 without additional purification.

후처리

  1. additionwas added
  2. customThe solvent was removed under reduced pressure
  3. customTo remove the excess oxalyl chloride the residue
  4. dissolutionwas dissolved in benzene
  5. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-4620a0c77b894392b254633f88f49861
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06589970B2

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