Bromine → 5-Bromo-6-methoxy-naphthalene-2-carbonitrile

HRID 1357284노트

반응식

HRID 1357284 반응식
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]#[N:16])[CH:9]=[CH:8]2>CC(O)=O>[Br:1][C:6]1[C:5]([O:4][CH3:3])=[CH:14][CH:13]=[C:12]2[C:7]=1[CH:8]=[CH:9][C:10]([C:15]#[N:16])=[CH:11]2

참가 물질

4

반응물 2

HCID 24408BromineHCID 3491736-Methoxynaphthalene-2-carbonitrile

생성물 1

HCID 185053355-Bromo-6-methoxy-naphthalene-2-carbonitrile수율 88%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

Bromine (7.0 mL, 0.137 mol) in 100 mL of glacial HOAc was added under nitrogen dropwise over 4 h to a solution of 6-methoxy-naphthalene-2-carbonitrile (25.02 g, 0.137 mol) in 700 mL of glacial HOAc at room temperature. After the addition the reaction was stirred at room temperature overnight. The solid that formed was collected by filtration, rinsed with glacial HOAc and dried under reduced pressure to give 5-bromo-6-methoxy-naphthalene-2-carbonitrile (31.35 g, 88%) as a white solid, mp 177-178° C.

후처리

  1. additionAfter the addition the reaction
  2. customThe solid that formed
  3. filtrationwas collected by filtration
  4. washrinsed with glacial HOAc
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-74ae69ad48b24a59abd662eb5ca083ec
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06589970B2

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