Piperazine → HCID 18186929, 화합물

HRID 1357637노트

반응식

HRID 1357637 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)[O:12][C:11]=2[CH3:22])[N:3]=1.ClC1C=CC(C2OC(C)=C(CO)C=2)=CC=1.[NH:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1.C([O-])([O-])=O.[K+].[K+]>>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([C:13]2[O:12][C:11]([CH3:22])=[C:10]([CH2:9][O:8][C:4]3[CH:5]=[N:6][CH:7]=[C:2]([N:38]4[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]4)[N:3]=3)[CH:14]=2)=[CH:16][CH:17]=1

참가 물질

5

반응물 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 7245332[5-(4-Chlorophenyl)-2-methylfuran-3-yl]methanolHCID 18186841HCID 18186841, 화합물

생성물 1

HCID 18186929HCID 18186929, 화합물

실험 절차

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[5-(4-chlorophenyl)-2-methylfuran-3-ylmethoxy]pyrazine [3.14 g, 9.39 mmol; obtained according to the procedure of example 50, step 1, starting from 5-(4-chlorophenyl)-3-hydroxymethyl-2-methylfuran], piperazine (2.47 g, 28.6 mmol) and K2CO3 (1.36 g, 9.86 mmol) with the exception that the final filtration through alumina was omitted. The yield of the of the title compound was 2.11 g (58%) which was obtained as a beige colored solid. Purity 100% (HPLC). MS m/z 384 (M)+. HRMS m/z calcd for C20H21ClN4O2 (M)+ 384.1353, found 384.1357.

후처리

  1. customobtained
  2. filtrationfiltration through alumina
  3. customwas obtained as a beige colored solid

출처 및 근거

ORD 기록
ord-e6f35c6d07e24413aefabc6bfbab6242
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06593330B2

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