Methanol → Doxifluridine

HRID 1358063

반응식

HRID 1358063 반응식
C([SnH](CCCC)CCCC)CCC.I[CH2:15][C@H:16]1[O:20][C@@H:19]([N:21]2[CH:28]=[C:27]([F:29])[C:25](=[O:26])[NH:24][C:22]2=[O:23])[C@H:18]([OH:30])[C@@H:17]1[OH:31].CO>C1(C)C=CC=CC=1>[F:29][C:27]1[C:25](=[O:26])[NH:24][C:22](=[O:23])[N:21]([CH:28]=1)[C@@H:19]1[O:20][C@H:16]([CH3:15])[C@@H:17]([OH:31])[C@H:18]1[OH:30]

참가 물질

5

반응물 3

HCID 887MethanolHCID 5948TributylstannaneHCID 108723875'-Deoxy-5'-iodo-5-fluorouridine

생성물 1

HCID 18343Doxifluridine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

When the reduction is carried out by using tributyltin hydride, the reaction takes place by dissolving 5′-deoxy-5′-iodo-5-fluorouridine in an alcohol, for example methanol, the reducing agent being added as a solution in an organic solvent, for example in toluene, and the mixture is heated at reflux in the presence of α,α′-azoisobutyro nitrile in catalytic amount. After 1÷3 hours the reduction is complete and, after evaporation of the solvent, the 5′-deoxy-5-fluorouridine thus obtained is recovered according to conventional methods.

후처리

  1. temperaturethe mixture is heated
  2. customAfter 1÷3 hours
  3. customafter evaporation of the solvent

출처 및 근거

ORD 기록
ord-e4e4832fa8694f1daf899ed2aee7ad27
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06593467B2

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