Methyl 5-nitro-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate → Methyl 5-amino-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate

HRID 1358127노트

반응식

HRID 1358127 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:14]2[C:19]([O:20][CH2:21][O:22][CH3:23])=[CH:18][CH:17]=[CH:16][C:15]=2[O:24][CH3:25])=[C:8]([CH:13]=1)[C:9]([O:11][CH3:12])=[O:10])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:14]2[C:19]([O:20][CH2:21][O:22][CH3:23])=[CH:18][CH:17]=[CH:16][C:15]=2[O:24][CH3:25])=[C:8]([CH:13]=1)[C:9]([O:11][CH3:12])=[O:10]

참가 물질

4

반응물 1

HCID 18189455Methyl 5-nitro-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate

생성물 1

HCID 18188782Methyl 5-amino-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of Example 32A (10.0 g) and 10% Pd/C (1.0 g) in methanol (200 mL) at room temperature was hydrogenated at 4 atm for 1 hour, filtered through diatomaceous earth (Celite®), and concentrated to provide the desired product. MS (ESI(−)QIMS) m/z 316 (M−H)−.

후처리

  1. filtrationfiltered through diatomaceous earth (Celite®)
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-29d2a0feb4eb42ae9701edf178423db3
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06593480B2

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