HCID 18184366, 화합물 → HCID 18184387, 화합물

HRID 1358263노트

반응식

HRID 1358263 반응식
[N+:1]([C:4]1[CH:12]=[C:11]([N+:13]([O-])=O)[C:10]([OH:16])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7])([O-])=O>CO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:12]=[C:11]([NH2:13])[C:10]([OH:16])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7]

참가 물질

4

반응물 1

HCID 18184366HCID 18184366, 화합물

생성물 1

HCID 18184387HCID 18184387, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584119Ethylacetate methanol용매

실험 절차

A solution of 2,4-dinitro-5-hydroxybenzamide (4.00 g, 0.018 mmol) in MeOH/EtOAc (1:1, 50 mL) is hydrogenated over 5% Pd/C at 60 psi for 3 h to give 2,4-diamino-5-hydroxybenzamide, which is used directly. Formic acid (50 mL) is added and the solution is heated under reflux for 48 h. then the volatiles are removed under reduced pressure. The residue is triturated with EtOAc to give crude 4-oxo-3H-oxazolo[5,4-g]quinazoline (3.27 g, 97%) as a tan powder which is used directly.

출처 및 근거

ORD 기록
ord-ac7dcea98dc74a988041834a5570fde8
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596726B1

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