HCID 21979562, 화합물 → HCID 18184267, 화합물

HRID 1358341

반응식

HRID 1358341 반응식
Cl[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH3:16])=[C:6]([Cl:17])[N:5]=[C:4]([CH:18]2[CH2:20][CH2:19]2)[N:3]=1.[K].[C:22]([C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH2:35])(=[O:34])=[O:33])=[CH:28][CH:27]=1)([CH3:25])([CH3:24])[CH3:23]>>[C:22]([C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH:35][C:2]2[C:7]([O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[O:15][CH3:16])=[C:6]([Cl:17])[N:5]=[C:4]([CH:18]3[CH2:20][CH2:19]3)[N:3]=2)(=[O:33])=[O:34])=[CH:28][CH:27]=1)([CH3:25])([CH3:23])[CH3:24]

참가 물질

3

반응물 2

HCID 21979562HCID 21979562, 화합물HCID 66748434p-t-Butylbenzenesulfonamide potassium

생성물 1

HCID 18184267HCID 18184267, 화합물

실험 절차

According to the procedure described in Example 1g) 3.3 g 4,6-dichloro-2-cyclopropyl-5-(o-methoxyphenoxy)-pyrimidine (prepared according to procedures described in Example 1) was reacted with 4-tert.-butylphenylsulfonamide potassium salt to give 4.22 g 4-tert.-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-cyclopropyl-pyrimidin-4-yl]-benzene-sulfonamide. LC-MS: tR=6.24 min, [M+1]+=488.23.

출처 및 근거

ORD 기록
ord-bb793a4f7b7e4309bb32a067284c8807
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596719B1

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