Ethanolamine → 5-methyl-N-[6-(2-aminoethoxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridine sulfonamide

HRID 1358365

반응식

HRID 1358365 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][C:12]2[C:17]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25][CH3:26])=[C:16](Cl)[N:15]=[C:14]([C:28]3[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=3)[N:13]=2)(=[O:10])=[O:9])=[N:6][CH:7]=1.[NH2:34][CH2:35][CH2:36][OH:37]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][C:12]2[C:17]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25][CH3:26])=[C:16]([O:37][CH2:36][CH2:35][NH2:34])[N:15]=[C:14]([C:28]3[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=3)[N:13]=2)(=[O:10])=[O:9])=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 700EthanolamineHCID 11202530HCID 11202530, 화합물

생성물 1

HCID 181842545-methyl-N-[6-(2-aminoethoxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridine sulfonamide

실험 절차

According to the procedure described in Example 4b) 1.0 g 5-methyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridine sulfonamide was reacted with 2-aminoethanol to give 950 mg 5-methyl-N-[6-(2-aminoethoxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrmidinyl]-2-pyridine sulfonamide. LC-MS: tR=3.00 min, (M+1]+=509.53, [M−1]−=507.57.

출처 및 근거

ORD 기록
ord-59374a89cbf542d0809acb294d6dd1b5
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596719B1

연결된 노트

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