Water → 4-Chloro-5-methyl-1H-indole-2,3-dione

HRID 1358477노트

반응식

HRID 1358477 반응식
[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4](SC)[C:5](=[O:12])[NH:6]2.ClN1C(=[O:21])CCC1=O.C1COCC1.O>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:21])[C:5](=[O:12])[NH:6]2

참가 물질

6

반응물 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 31398ChlorosuccinimideHCID 219059304-Chloro-5-methyl-3-(methylthio)indolin-2-one

생성물 1

HCID 225608594-Chloro-5-methyl-1H-indole-2,3-dione수율 80.9%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

This compound is prepared according to the procedure described in stage B of Preparation 1.10 from 0.72 g of 4-chloro-5-methyl-3-methylthio-1,3-dihydro-2H-indol-2-one and 0.422 g of N-chlorosuccinimide in 72 ml of carbon tetrachloride and then from 58 ml of THF and 14 ml of water. The product obtained is chromatographed on silica gel, elution being carried out with DCM and then with the gradient of the DCM/AcOEt mixture up to (90/10, v/v). 0.5 g of the expected product is obtained.

후처리

  1. customThis compound is prepared
  2. customThe product obtained
  3. customis chromatographed on silica gel, elution

출처 및 근거

ORD 기록
ord-089851175b4f43688e6648d1ecc71ad6
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596732B2

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