Cesium carbonate → HCID 21137722, 화합물

HRID 1358580노트

반응식

HRID 1358580 반응식
[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH2:20]C1C=CC(O)=CC=1)[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.Br[CH2:30][C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32].C(=O)([O-])[O-:39].[Cs+].[Cs+]>CC(C)=O>[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH3:20])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:39][CH2:30][C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[CH:8][C:7]=1[C:12](=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 79177tert-Butyl bromoacetateHCID 10667178N-(2-benzoylphenyl)tyrosine methyl ester

생성물 1

HCID 21137722HCID 21137722, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of N-(2-benzoylphenyl)tyrosine methyl ester (0.97 g), t-butyl bromoacetate (0.55 ml), cesium carbonate (1.14 g), and acetone (15 ml) was stirred at room temperature for 1.5 hours and allowed to stand overnight. The reaction mixture was partitioned between ethyl acetate and water. The extract was washed with saturated aqueous chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the title compound (1.42 g, Rf=0.65: thin layer chromatography on a silica gel plate using hexane: ethyl acetate=3:1 as the eluant).

후처리

  1. waitto stand overnight
  2. customThe reaction mixture was partitioned between ethyl acetate and water
  3. washThe extract was washed with saturated aqueous chloride solution
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1963ac32b3a04352b8a8fc389959067b
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596751B2

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