Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 4-Trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1-Chloro-4-(trifluoromethylsulfonyl)benzene | HCID 703324 | — |
| 반응물 | 4-((Trifluoromethyl)thio)benzenemethanol | HCID 2777870 | — |
| 생성물 | 4-Trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether | HCID 18185327 | 66.7% |
반응 단계
4-(Trifluoromethylthio)benzyl alcohol (300 mg, 1.44 mmol) was coupled with 4-(trifluoromethylsulfonyl)chlorobenzene (370 mg, 1.51 mmol) using sodium hydride (65 mg, 60% dispersion in oil, 1.58 mmol) to give 400 mg of 4-trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether as a white solid. 1HNMR (360 MHz, DMSO-d6) δ 8.06 (d, J=8.4 Hz, 2H), 7.77 (d, J=8.4 Hz, 2H), 7.63 (d, J=8.4 Hz, 2H), 7.43 (d, J=8.4 Hz, 2H), 5.39 (s, 2H, OCH2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06596772B1 |
| 출처 데이터셋 | uspto-grants-2003_07 |
| ORD ID | ord-66643039a25840489d0b0e062542870d |
| 출처 메모 | uspto-grants-2003_07 |