Flecainide → 2,2,2-Trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

HRID 1359120

반응식

HRID 1359120 반응식
[CH:1]1[C:6]([O:7][CH2:8][C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]([C:13](NCC2NCCCC2)=[O:14])=[C:3]([O:23][CH2:24][C:25]([F:28])([F:27])[F:26])[CH:2]=1.OC1C=CC(O)=CC=1C(O)=O.FC(F)(S([O:55][CH2:56][C:57]([F:60])([F:59])[F:58])(=O)=O)C(F)(F)C(F)(F)C(F)(F)F>>[F:27][C:25]([F:26])([F:28])[CH2:24][O:23][C:3]1[CH:2]=[CH:1][C:6]([O:7][CH2:8][C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[C:13]([O:55][CH2:56][C:57]([F:60])([F:59])[F:58])=[O:14]

참가 물질

4

반응물 3

HCID 3356FlecainideHCID 34692,5-Dihydroxybenzoic acidHCID 27771442,2,2-Trifluoroethyl perfluorobutylsulfonate

생성물 1

HCID 112810142,2,2-Trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

실험 절차

Process for the synthesis of FLECAINIDE comprising the reaction between 2,5-dihydroxybenzoic acid with trifluoroethanol perfluorobutanesulphonate to give the intermediate trifluoroethanol 2,5-bis-trifluoroethoxybenzoate, the reaction of said intermediate with 2-aminomethylpiperidine to give FLECAINIDE.

출처 및 근거

ORD 기록
ord-362bf334465f4aea9bd4cda8d16c6c78
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06599922B2

연결된 노트

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