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Potassium Carbonate → (3R)-3-ethynyl-1-azabicyclo[2.2.2]octan-3-ol

HRID 1359287
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인쇄 미리보기

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HRID 1359287 반응식
[C:1]([C@:3]1([OH:11])[CH:8]2[CH2:9][CH2:10][N:5]([CH2:6][CH2:7]2)[CH2:4]1)#[CH:2].C([C@@H]([C@H](C([O-])=O)O)O)([O-])=O.C(=O)([O-])[O-].[K+].[K+]>O>[C:1]([C@:3]1([OH:11])[CH:8]2[CH2:9][CH2:10][N:5]([CH2:6][CH2:7]2)[CH2:4]1)#[CH:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 86759091(3R)-3-ethynyl-3-quinuclidinol L-(+)-tartrate

생성물 1

HCID 946095(3R)-3-ethynyl-1-azabicyclo[2.2.2]octan-3-ol수율 87.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

15.6 g of (3R)-3-ethynyl-3-quinuclidinol +L-(+)-tartrate was dissolved in 150 ml of water and 20 g of anhydrous potassium carbonate was added little by little under stirring. The resulting crystal were collected by filtration, washed with water and then dried, to give 6.88 g of the title compound.

후처리

  1. filtrationThe resulting crystal were collected by filtration
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-ed782d19f4df4c6a9d28b0d3785c9ff5
출처 데이터셋
uspto-grants-2003_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06599917B1

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