Acetone → 1-Methoxy-3-phenylpropan-2-one

HRID 1359416노트

반응식

HRID 1359416 반응식
CC(C)=O.[CH3:5][O:6][CH2:7][CH:8]([OH:16])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CC(O)C>[CH3:5][O:6][CH2:7][C:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:16]

참가 물질

4

반응물 2

HCID 180AcetoneHCID 135125601-Methoxy-3-phenyl-2-propanol

생성물 1

HCID 117449711-Methoxy-3-phenylpropan-2-one수율 73.4%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

20.4 ml of a Jone's reagent was slowly added dropwise into 200 ml of an acetone solution containing 5.1 g of 1-methoxy-3-phenyl-2-propanol. After stirring for 30 minutes at room temperature, 30 ml of 2-propanol was slowly added to the reaction solution. After removing the solvent, water was added thereto and the mixture was extracted with ethyl acetate. The organic phase was washed with brine and the solvent was removed. The residue was subjected to silica gel column chromatography and elute with hexane/ethyl acetate (6:1), to give 3.7 g of the target compound.

후처리

  1. customAfter removing the solvent, water
  2. additionwas added
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic phase was washed with brine
  5. customthe solvent was removed
  6. washelute with hexane/ethyl acetate (6:1)

출처 및 근거

ORD 기록
ord-476b05a3d40b4c35bc563713a6029d38
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06599917B1

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