Ammonia → Imidazo[2,1-b]thiazole-6-methanol, 2,3-dihydro-, 1,1-dioxide

HRID 1359445노트

반응식

HRID 1359445 반응식
C([O:4][CH2:5][C:6]1[N:7]=[C:8]2[N:12]([CH:13]=1)[CH2:11][CH2:10][S:9]2(=[O:15])=[O:14])(=O)C.N>>[OH:4][CH2:5][C:6]1[N:7]=[C:8]2[N:12]([CH:13]=1)[CH2:11][CH2:10][S:9]2(=[O:15])=[O:14]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 18183092HCID 18183092, 화합물

생성물 1

HCID 18183097Imidazo[2,1-b]thiazole-6-methanol, 2,3-dihydro-, 1,1-dioxide

실험 절차

6-Acetoxymethyl-2,3-dihydroimidazo[2,1-b]thiazole-1,1-dioxide (305 mg, 1.33 mmol) was treated with methanolic ammonia (prepared by saturating methanol (20 ml) with ammonia gas then diluting with more methanol (20 ml)) at room temperature. After 2.5 h, the volatiles were removed under reduced pressure and the residue triturated with diethyl ether and the resulting solid collected by filtration, washed with diethyl ether and dried in air (207 mg, 83%) (Found: M30 188.0256. C6H8N2O3S requires M 188.0256); νmax (nujol) 3354, 1377, 1325 and 1133 cm−1; δH [250 MHz; (CD3)2SO] 4.14 (2H, t, J 6 Hz), 4.40 (2H, d, J 6 Hz), 4.54 (2H, t, J 6 Hz), 5.20 (1H, t, J 6 Hz, exchangeable), 7.36 (1H, s).

후처리

  1. customprepared
  2. concentrationby saturating methanol (20 ml) with ammonia gas
  3. additionthen diluting with more methanol (20 ml)) at room temperature
  4. customthe volatiles were removed under reduced pressure
  5. customthe residue triturated with diethyl ether
  6. filtrationthe resulting solid collected by filtration
  7. washwashed with diethyl ether
  8. customdried in air (207 mg, 83%) (Found: M30 188.0256. C6H8N2O3S requires M 188.0256)

출처 및 근거

ORD 기록
ord-49374817b495481c9e4fb6f05e4135ce
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06600035B1

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