5-Nitroso-2,4,6-pyrimidinetriamine → Pyrimido[5,4-g]pteridine

HRID 1359457

반응식

HRID 1359457 반응식
N[C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N:9]=O)=[C:4](N)[N:3]=1.N[C:13]1[N:18]=[C:17](N)[CH:16]=[C:15](O)[N:14]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)(=O)C>[N:14]1[C:15]2[C:16](=[N:9][C:5]3[CH:4]=[N:3][CH:2]=[N:7][C:6]=3[N:8]=2)[CH:17]=[N:18][CH:13]=1

참가 물질

5

반응물 3

HCID 705045-Nitroso-2,4,6-pyrimidinetriamineHCID 521998p-Toluenesulfonic acid monohydrateHCID 178507952HCID 178507952, 화합물

생성물 1

HCID 18183250Pyrimido[5,4-g]pteridine

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
113 °C

실험 절차

A suspension of 6.20 g of commercial 2,4,6-triamino-5-nitrosopyrimidine (Chemie Uetikon, Lahr, Germany), 5.15 g of commercial 2,4-diamino-6-hydroxypyrimidine (Fluka, Buchs, Switzerland) and 11.52 g of commercial toluene-4-sulfonic acid monohydrate in 110 ml of glacial acetic acid (100%) is stirred for 20 hours at 113° C. The reaction mixture is filtered off over a laminated paper filter while still hot, and the residue is washed with hot water (approx. 60° C.) until the pH of the washing water has reached a value of at least 4. The washed residue, moist with water, is dried in vacuo at 110° C. to yield a greenish-yellow powder of the pyrimido[5,4-g]pteridine salt of formula VI

후처리

  1. filtrationThe reaction mixture is filtered off over a laminated paper
  2. filtrationfilter while still hot, and the residue
  3. washis washed with hot water (approx. 60° C.) until the pH of the washing water
  4. dry with materialThe washed residue, moist with water, is dried in vacuo at 110° C.

출처 및 근거

ORD 기록
ord-25f08e75f34546e1b4f409b362314710
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06600042B1

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