Sulfamic Acid → Pyrimido[5,4-g]pteridine

HRID 1359458

반응식

HRID 1359458 반응식
N[C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N:9]=O)=[C:4](N)[N:3]=1.N[C:13]1[N:18]=[C:17](N)[CH:16]=[C:15](O)[N:14]=1.S(=O)(=O)(O)N>O>[N:14]1[C:15]2[C:16](=[N:9][C:5]3[CH:4]=[N:3][CH:2]=[N:7][C:6]=3[N:8]=2)[CH:17]=[N:18][CH:13]=1

참가 물질

5

반응물 3

HCID 5987Sulfamic AcidHCID 705045-Nitroso-2,4,6-pyrimidinetriamineHCID 178507952HCID 178507952, 화합물

생성물 1

HCID 18183250Pyrimido[5,4-g]pteridine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
84 °C

실험 절차

A mixture of 6.20 g of commercial 2,4,6-triamino-5-nitrosopyrimidine, 5.15 g of 2,4-diamino-6-hydroxypyrimidine and 3.92 g of sulfamic acid in 230 ml of water is finely stirred for one minute by means of an ULTRA-TURRAX® stirring rod and heated to a temperature in the range of from 82 to 86° C. The mixture is stirred at that temperature for 17 hours and then filtered over a laminated paper filter while still hot. The residue is washed with hot water until the pH of the washing water is above 4. After drying in vacuo at 110 ° C., there are obtained 10.28 g (75% of the theoretical yield) of a light-yellow powder of the pyrimido-[5,4-g]pteridine salt of formula IV, the acid being sulfamic acid.

후처리

  1. stirringstirring rod
  2. stirringThe mixture is stirred at that temperature for 17 hours
  3. filtrationfiltered over a laminated paper
  4. filtrationfilter while still hot
  5. washThe residue is washed with hot water until the pH of the washing water
  6. customAfter drying in vacuo at 110 ° C.
  7. customthere are obtained 10.28 g (75% of the

출처 및 근거

ORD 기록
ord-9402a21072144e849d08900047dc3c6d
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06600042B1

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