Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 4-Methylphenyl-2-propenal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Lilac acetaldehyde | HCID 61006 | — |
| 반응물 | Dimethyl(methylene)ammounium iodide | HCID 2724133 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 4-Methylphenyl-2-propenal | HCID 18000904 | — |
반응 단계
2.57 g of aldehyde 37 is introduced into 300 ml of methylene chloride under nitrogen, and 6.5 ml of triethylamine and 7.1 g of Eschenmoser's salt are added at 0° C. After 2.5 hours at 0° C., saturated ammonium chloride solution is added, extracted with methylene chloride, washed with sodium chloride solution, dried on sodium sulfate and concentrated by evaporation. The residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 1.94 g of title compound 38 accumulates as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06600058B1 |
| 출처 데이터셋 | uspto-grants-2003_07 |
| ORD ID | ord-c1a219dc11c04ea39e0ffd325dee711f |
| 출처 메모 | uspto-grants-2003_07 |