Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Salicyl Alcohol → [2-(2-Morpholinoethoxy)phenyl]methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Salicyl Alcohol | HCID 5146 | — |
| 반응물 | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | [2-(2-Morpholinoethoxy)phenyl]methanol | HCID 7164615 | — |
반응 단계
A mixture of 2-hydroxybenzyl alcohol (1.295 g, 10.4 mmol) and 4-(2-chloroethyl)morpholine hydrochloride (1.94 g, 10.4 mmol) in 2N NaOH (10.5 mL) was stirred at rt for 14 hours. The precipitate was collected by vacuum filtration, washed with 1N NaOH, redissolved in DCM and washed with 1N NaOH. The aqueous layer was extracted with more DCM (2×). The combined DCM was dried and concentrated to give [2-(2-morpholin-4-yl-ethoxy)-phenyl]-methanol which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06599902B2 |
| 출처 데이터셋 | uspto-grants-2003_07 |
| ORD ID | ord-7b584bb1f44649918b9acb5561442590 |
| 출처 메모 | uspto-grants-2003_07 |