(R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate → (R)-Pyrrolidin-2-YL-pyrrolidin-1-YL-methanone

HRID 1359741

반응식

HRID 1359741 반응식
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C@@H:12]1[C:16]([N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)=[O:17])=O)C1C=CC=CC=1>CO.[Pd]>[N:18]1([C:16]([C@H:12]2[CH2:13][CH2:14][CH2:15][NH:11]2)=[O:17])[CH2:19][CH2:20][CH2:21][CH2:22]1

참가 물질

4

반응물 1

HCID 667614(R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

생성물 1

HCID 10034997(R)-Pyrrolidin-2-YL-pyrrolidin-1-YL-methanone

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

(R)-2-(pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester was hydrogenated using Pd/C in methanol at rt for 20 hours to give pyrrolidin-1-yl-(R)-pyrrolidin-2-yl-methanone.

후처리

  1. customat rt
  2. customfor 20 hours

출처 및 근거

ORD 기록
ord-8ce7a5ee3fe64a599e26134685ec6fe1
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06599902B2

연결된 노트

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