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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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5-(2,6-Difluoro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one → 3-[1-[4-((s)-2-Cyclopropylaminomethyl-pyrrolidine-1-carbonyl)-3,5-dimethyl-1h-pyrrol-2-yl]-meth-(z)-ylidene]-5-(2,6-difluoro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one

HRID 1359767
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인쇄 미리보기

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HRID 1359767 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=[O:12])=[O:11].[CH:23]1([NH:26][CH2:27][C@@H:28]2[CH2:32][CH2:31][CH2:30][N:29]2[C:33]([C:35]2[C:36]([CH3:43])=[C:37]([CH:41]=O)[NH:38][C:39]=2[CH3:40])=[O:34])[CH2:25][CH2:24]1>N1CCCCC1.C(O)C>[CH:23]1([NH:26][CH2:27][C@@H:28]2[CH2:32][CH2:31][CH2:30][N:29]2[C:33]([C:35]2[C:36]([CH3:43])=[C:37](/[CH:41]=[C:16]3\[C:17](=[O:22])[NH:18][C:19]4[C:15]\3=[CH:14][C:13]([S:10]([CH2:9][C:3]3[C:2]([F:1])=[CH:7][CH:6]=[CH:5][C:4]=3[F:8])(=[O:12])=[O:11])=[CH:21][CH:20]=4)[NH:38][C:39]=2[CH3:40])=[O:34])[CH2:24][CH2:25]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 181799315-(2,6-Difluoro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-oneHCID 865886154-((S)-2-cyclopropylaminomethyl-pyrrolidine-1-carbonyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde

생성물 1

HCID 590777583-[1-[4-((s)-2-Cyclopropylaminomethyl-pyrrolidine-1-carbonyl)-3,5-dimethyl-1h-pyrrol-2-yl]-meth-(z)-ylidene]-5-(2,6-difluoro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one

시약·촉매·용매 2

HCID 8082Piperidine
촉매
HCID 702Ethanol용매

실험 절차

A mixture of 5-(2,6-difluoro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one (280 mg, 0.87 mmol), 4-((S)-2-cyclopropylaminomethyl-pyrrolidine-1-carbonyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde (250 mg, 0.86 mmol) and piperidine (2 drops) in ethanol (2 mL) was stirred at rt for 4 days. The reaction was concentrated and purified on a silica gel column to give the titled compound.

후처리

  1. concentrationThe reaction was concentrated
  2. custompurified on a silica gel column

출처 및 근거

ORD 기록
ord-85377515695449c09b1221ba117aaa9c
출처 데이터셋
uspto-grants-2003_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06599902B2

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