Cyclopropanemethanamine → 5-[5-(2,6-Dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Cyclopropylmethyl-amide

HRID 1359776노트

반응식

HRID 1359776 반응식
N1C2C(=NC=CC=2)N([O:10][C:11]([C:13]2[C:17]([CH3:18])=[C:16](/[CH:19]=[C:20]3\[C:21](=[O:41])[NH:22][C:23]4[C:28]\3=[CH:27][C:26]([S:29]([CH2:32][C:33]3[C:38]([Cl:39])=[CH:37][CH:36]=[CH:35][C:34]=3[Cl:40])(=[O:31])=[O:30])=[CH:25][CH:24]=4)[NH:15][C:14]=2[CH3:42])=O)N=1.[CH:43]1([CH2:46][NH2:47])[CH2:45][CH2:44]1>CC(N(C)C)=O>[CH:43]1([CH2:46][NH:47][C:11]([C:13]2[C:17]([CH3:18])=[C:16](/[CH:19]=[C:20]3\[C:21](=[O:41])[NH:22][C:23]4[C:28]\3=[CH:27][C:26]([S:29]([CH2:32][C:33]3[C:34]([Cl:40])=[CH:35][CH:36]=[CH:37][C:38]=3[Cl:39])(=[O:30])=[O:31])=[CH:25][CH:24]=4)[NH:15][C:14]=2[CH3:42])=[O:10])[CH2:45][CH2:44]1

참가 물질

4

반응물 2

HCID 75646CyclopropanemethanamineHCID 137178925HCID 137178925, 화합물

생성물 1

HCID 590777365-[5-(2,6-Dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Cyclopropylmethyl-amide

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

To a solution of 5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid [1,2,3]triazolo[4,5-b]pyridin-3-yl ester (100 mg, 0.162 mmol) in DMA (2 mL) was added C-cyclopropyl-methylamine (23 mg, 2 eq.). The mixture was stirred at rt for 18 hours. The reaction was concentrated, diluted with DCM, washed with sat.NaHCO3 and water, concentrated and triturated with methanol to give the titled compound as a yellow solid.

후처리

  1. concentrationThe reaction was concentrated
  2. additiondiluted with DCM
  3. washwashed
  4. concentrationNaHCO3 and water, concentrated
  5. customtriturated with methanol

출처 및 근거

ORD 기록
ord-96a41657505741c4bfdd7f10a1244b68
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06599902B2

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