Piperidine → 3-[1-{3,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrol-2-yl}-meth-(z)-ylidene]-5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one

HRID 1359777노트

반응식

HRID 1359777 반응식
[C:1]1([CH2:7][S:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][C:22]1[C:26]([CH2:27][C:28](=[O:40])[N:29]2[CH2:33][CH2:32][CH2:31][C@H:30]2[CH2:34][N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:25]([CH3:41])[NH:24][C:23]=1[CH:42]=O.N1CCCCC1>C(O)C>[CH3:21][C:22]1[C:26]([CH2:27][C:28](=[O:40])[N:29]2[CH2:33][CH2:32][CH2:31][C@H:30]2[CH2:34][N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:25]([CH3:41])[NH:24][C:23]=1/[CH:42]=[C:14]1\[C:15](=[O:20])[NH:16][C:17]2[C:13]\1=[CH:12][C:11]([S:8]([CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)(=[O:10])=[O:9])=[CH:19][CH:18]=2

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 21139221HCID 21139221, 화합물HCID 880943273,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrole-2-carbaldehyde

생성물 1

HCID 590774823-[1-{3,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrol-2-yl}-meth-(z)-ylidene]-5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one (100 mg, 0.35 mmol), 3,5-dimethyl-4-[2-oxo-2-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1H-pyrrole-2-carbaldehyde (110 mg, 1 eq.) and piperidine (0.5 eq.) in ethanol (2 mL) was stirred at rt for 48 hours. The reaction was concentrated, triturated with methanol, filtered and washed wit DCM to give the titled compound as a pale orange solid.

후처리

  1. concentrationThe reaction was concentrated
  2. customtriturated with methanol
  3. filtrationfiltered
  4. washwashed wit DCM

출처 및 근거

ORD 기록
ord-62c45ba6a11345dfb83cc31995f68e80
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06599902B2

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