HCID 69997310, 화합물 → (2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide

HRID 1359804노트

반응식

HRID 1359804 반응식
C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([OH:13])[C@H:9]1[C:14](=[O:19])[NH:15][CH:16]1[CH2:18][CH2:17]1)=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH:16]1([NH:15][C:14]([C@@H:9]2[C@@H:10]([OH:13])[CH2:11][CH2:12][NH:8]2)=[O:19])[CH2:18][CH2:17]1

참가 물질

4

반응물 1

HCID 69997310HCID 69997310, 화합물

생성물 1

HCID 69998139(2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide수율 99.3%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of (2S,3S)-2-cyclopropylcarbamoyl-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (5.6 g) in 30% of TFA in DCM (50 mL) was stirred at rt for 2 hours. The reaction was concentrated to give 3.5 g of (2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide as a TFA salt.

후처리

  1. concentrationThe reaction was concentrated

출처 및 근거

ORD 기록
ord-8716aea6608b44878e8327663f1126dc
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06599902B2

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