Chloroacetonitrile → 2-(4-Hydroxypiperidin-1-YL)acetonitrile
반응식
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.Cl[CH2:9][C:10]#[N:11].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:9][C:10]#[N:11])[CH2:4][CH2:3]1참가 물질
5
실험 절차
A mixture of 4-hydroxypyridine (4.04 g, 40 mmol), chloroacetonitrile (2.78 mL, 44 mmol) and potassium carbonate (22 g, 160 mmol) in acetonitrile (50 mL) was stirred at rt for overnight. The insolubles were filtered off, the filtrate was concentrated to give 5.6 g of (4-hydroxy-piperidin-1-yl)-acetonitrile.
후처리
- filtrationThe insolubles were filtered off
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-9b2ecec2ff064a87b51db3bf718a57b7
- 출처 데이터셋
- uspto-grants-2003_07
- 특허 번호
- US06599902B2
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