Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 136생성일: 2026년 10월 23일
3-Aminoazetidine, 3-BOC protected → tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate
https://huagongshe.com/ko/reaction/136
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Aminoazetidine, 3-BOC protected | HCID 1519405 | — |
| 반응물 | 4-Bromo-2-methoxypyridine | HCID 14062309 | — |
| 시약 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | Binap, (A+-)- | HCID 634876 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate | HCID 118055029 | 100.28% |
반응 단계
A mixture of all the reactants in toluene was heated in a sealed vial at 70 °C overnight. According to LC-MS the reaction was completed and the product had been formed. Toluene was removed, water was added and the product was extracted with DCM. The organic phase was dried through phase separator and concentrated. The crude was used without further purification in the next step, EN01762-02.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-3870c5bc1f6548e38bd05a0e29b91f59 |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
