Ethyl 2-hydroxy-5-(4-methoxyphenyl)pentanoate → Ethyl (2R)-2-hydroxy-5-(4-methoxyphenyl)pentanoate

반응식

O[C@H](CCCC1C=CC(OC)=CC=1)C(O)=O.[OH:17][CH:18]([CH2:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[OH:17][C@H:18]([CH2:24][CH2:25][CH2:26][C:27]1[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20]

참가 물질

반응물 2

HCID 16128914Ethyl 2-hydroxy-5-(4-methoxyphenyl)pentanoate

HCID 57880329(2R)-2-hydroxy-5-(4-methoxyphenyl)pentanoic acid

생성물 1

HCID 11644522Ethyl (2R)-2-hydroxy-5-(4-methoxyphenyl)pentanoate

실험 절차

Using (2R)-2-hydroxy-5-(4-methoxy-phenyl)pentanoic acid (80% e.e.), ethyl 2-hydroxy-5-(4-methoxyphenyl)pentanoate was quantitatively obtained (80% e.e.) by a process similar to the process described in Reference Example 27. The optical purity analysis conditions are as follows: Column: AD-H (Chiralcel, DAICEL Chemical Industries Ltd.)

후처리

customwas quantitatively obtained (80% e.e.) by a process similar to the process

출처 및 근거

ORD 기록: ord-1fd94ab8c6dd438695a4f077b219516d
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07879843B2

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