Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-(Benzyloxy)-3-nitrobenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Methyl 4-benzyloxy-3-nitrobenzoate | HCID 289857 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(Benzyloxy)-3-nitrobenzoic acid | HCID 16124725 | 95% |
반응 단계
A solution the crude 4-benzyloxy-3-nitro-benzoic acid methyl ester from the previous step in tetrahydrofurane (150 mL) and MeOH (600 mL) was treated with KOH 3N (152 mL) and stirred at room temperature for 18 hours. The mixture was acidified with HCl 3N. The precipitate thus formed was filtered, washing with MeOH/water 1:1 and dried under vacuum. 4-Benzyloxy-3-nitro-benzoic acid (42 g, 95% over two steps) was obtained as a white solid, which was used crude in the following reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07879845B2 |
| 출처 데이터셋 | uspto-grants-2011_02 |
| ORD ID | ord-67d2cc2522e543f08b13be6214d4fa13 |
| 출처 메모 | uspto-grants-2011_02 |