참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | (4-Bromo-2-nitrophenyl)methanol | HCID 15906236 | — |
| 촉매 | Iron | HCID 23925 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (2-Amino-4-bromophenyl)methanol | HCID 53440895 | 95% |
반응 단계
A mixture of (4-bromo-2-nitro-phenyl)-methanol (1.85 g, 7.97 mmol), iron powder (2.23 g, 39.9 mmol), ammonium chloride (213 mg, 3.99 mmol), ethanol (20 mL), and water (10 mL) was heated at 75° C. for 1 h, then after cooling filtered through a pad of diatomaceous earth. The filtrate was evaporated and the residue partitioned between ethyl acetate and water, the organic layer was washed with brine, dried (MgSO4), and evaporated to produce (2-amino-4-bromo-phenyl)-methanol (1.53 g, 90%). Off-white solid, MS (EI)=201.0 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07879845B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_02 |
|---|
| ORD ID | ord-750b8360f5894fb8a77b7e6101fc8346 |
|---|
| 출처 메모 | uspto-grants-2011_02 |
|---|
