Ammonium Hydroxide → 5-ethyl-1-methyl-1H-pyrazole-3-carboxamide

반응식

[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]([O:11]CC)=O)[CH:4]=1)[CH3:2].[OH-].[NH4+:15]>>[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]([NH2:15])=[O:11])[CH:4]=1)[CH3:2]

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 22145397Ethyl 5-ethyl-1-methyl-1H-pyrazole-3-carboxylate

생성물 1

HCID 669585825-ethyl-1-methyl-1H-pyrazole-3-carboxamide

실험 절차

A mixture of ethyl 5-ethyl-1-methyl-1H-pyrazole-3-carboxylate (5.03 g, 27.6 mmol) and ammonium hydroxide (28 mL of 30%) was stirred for 18 hours at ambient temperature. A precipitate formed, was isolated by filtration, and washed with cold hexanes to provide 2.60 g of 5-ethyl-1-methyl-1H-pyrazole-3-carboxamide as a white solid, mp 170-172° C.

후처리

customA precipitate formed
customwas isolated by filtration
washwashed with cold hexanes

출처 및 근거

ORD 기록: ord-6e05ae1195f945b4858dec2d52c7545d
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07879849B2

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