(3-((tert-Butoxycarbonyl)amino)pyridin-4-yl)boronic acid → tert-butyl 2-(4-amino-2-propyl-2H-pyrazolo[3,4-c][1,7]naphthyridin-1-yl)ethylcarbamate

HRID 1360587노트

반응식

HRID 1360587 반응식
[NH2:1][C:2]1[C:11]2=[N:12][N:13]([CH2:25][CH2:26][CH3:27])[C:14]([CH2:15][CH2:16][NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[C:10]2[C:9]2[CH:8]=[CH:7]C=[CH:5][C:4]=2[N:3]=1.C(OC([NH:35]C1C=NC=CC=1B(O)O)=O)(C)(C)C>>[NH2:1][C:2]1[C:11]2=[N:12][N:13]([CH2:25][CH2:26][CH3:27])[C:14]([CH2:15][CH2:16][NH:17][C:18](=[O:24])[O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[C:10]2[C:9]2[CH:8]=[CH:7][N:35]=[CH:5][C:4]=2[N:3]=1

참가 물질

3

반응물 2

HCID 15366412(3-((tert-Butoxycarbonyl)amino)pyridin-4-yl)boronic acidHCID 66958848tert-butyl 2-(4-amino-2-propyl-2H-pyrazolo[3,4-c]quinolin-1-yl)ethylcarbamate

생성물 1

HCID 66959244tert-butyl 2-(4-amino-2-propyl-2H-pyrazolo[3,4-c][1,7]naphthyridin-1-yl)ethylcarbamate수율 20.4%

실험 절차

A modification of the method described in Example 610 was used to couple tert-butyl 2-(4-amino-2-propyl-2H-pyrazolo[3,4-c]quinolin-1-yl)ethylcarbamate (2.08 g, 5.82 mmol) (Example 51, Parts A through G) with 3-[(tert-butoxycarbonyl)amino]pyridin-4-ylboronic acid (2.77 g, 11.6 mmol). After the first purification by IFC, 0.44 g of tert-butyl 2-(4-amino-2-propyl-2H-pyrazolo[3,4-c][1,7]naphthyridin-1-yl)ethylcarbamate was obtained as a yellow solid.

후처리

  1. customAfter the first purification by IFC

출처 및 근거

ORD 기록
ord-ddbbc949e372414fa05c7ecb15bde2d8
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879849B2

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